Thermal Analysis in the Pharmaceutical Research and Drug Development

Authors

  • L. Seilerová Department of Solid State Chemistry, Institute of Chemical Technology, Prague
  • H. Brusová Zentiva Co., Praha
  • B. Kratochvíl Department of Solid State Chemistry, Institute of Chemical Technology, Prague
  • L. Krejčík Zentiva Co., Praha

Keywords:

thermal methods, pharmaceutical development, DSC, glass transition, polymorphism, compatibility

Abstract

Thermal analysis is a valuable method in pharmaceutical research. A wide range of thermal methods are used in drug development like thermogravimetry (TG), diffe­rential thermal analysis (DTA), differential scanning calori­metry (DSC) and other sensitive and specific methods. The present review deals with application of these me­thods in characterization of drugs and excipients, such as their polymorph stability, glass transition temperature, purity analysis and compatibility of drugs.

Downloads

Published

2012-10-15

How to Cite

Seilerová, L., Brusová, H., Kratochvíl, B., & Krejčík, L. (2012). Thermal Analysis in the Pharmaceutical Research and Drug Development. Chemické Listy, 106(10), 890–895. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/828

Issue

Vol. 106 No. 10 (2012)

Section

Articles